Comparative carcinogenicity of some derivatives of nitrosodi-n-propylamine in rats.

Occurrence of part per million levels of N-nitrosodi-n-propylamine in various dinitroaniline herbicides may result in release of small amounts of the nitrosamine into the atmosphere during and after application

N-nitrosodi-n-propylamine is not an industrially or commercially important chemical. It is produced in small, laboratory-scale quantities for research purposes. It is also produced inadvertently during certain manufacturing processes, occurring as an impurity in some dinitroaniline pesticides and during manufacture of some extruded rubber products. Nitrosodi­ n-propylamine could also be present...

ADDENDUM TO THE TOXICOLOGICAL PROFILE FOR N-NITROSODI-N-PROPYLAMINE Agency for Toxic Substances and Disease Registry Division of Toxicology and Environmental Medicine

Anion exchange resins as a source of nitrosamines and nitrosamine precursors.

Anion exchange resins are important tools for the removal of harmful anionic contaminants from drinking water, but their use has been linked to the presence of carcinogenic nitrosamines in treated drinking water. In bench-scale batch and column experiments, anion exchange resins from a large, representative group were investigated as sources of the nitrosamines N-nitrosodimethylamine (NDMA), N-...

Occurrence and source of nitrosamines and secondary amines in groundwater and its adjacent Jialu River basin, China.

The presence of mutagenic and carcinogenic nitrosamines in groundwater is of great concern. In this study, eight nitrosamines including N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosomethylethylamine (NMEA), N-nitrosopyrrolidine (NPYR), N-nitrosomorpholine (NMOR), N-nitrosopiperidine (NPIP), N-nitrosodi-n-propylamine (NDPA), and N-nitrosodi-n-butylamine (NDBA) and corresp...

Dose-response curves for liver DNA fragmentation induced in rats by sixteen N-nitroso compounds as measured by viscometric and alkaline elution analyses.

A new viscometric technique, capable of detecting DNA strand breaks and alkali-labile sites by monitoring time-dependent changes of DNA-reduced viscosity, has been used to analyze dose-response curves for the induction of DNA damage in liver of rats treated with single p.o. doses of sixteen N-nitroso compounds. Statistically significant changes of DNA viscometric parameters, which are considere...